abstract：:Phosphorylation of glycogen has been known for decades; however, the basic metabolic pathways responsible for this modification are unknown. In this issue, Tagliabracci et al. (2011) report the enzyme responsible for incorporating phosphate and the chemical nature of the phosphate linkage, providing a framework for ex...

journal_title：Cell metabolism

authors： Worby CA,Dixon JE

更新日期：2011-03-02 00:00:00

abstract：:Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via ...

journal_title：Cell metabolism

authors： Song WJ,Seshadri M,Ashraf U,Mdluli T,Mondal P,Keil M,Azevedo M,Kirschner LS,Stratakis CA,Hussain MA

更新日期：2011-03-02 00:00:00

abstract：:In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK...

journal_title：Cell metabolism

authors： Asher G,Schibler U

更新日期：2011-02-02 00:00:00

abstract：:AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion. ...

journal_title：Cell metabolism

authors： Ferré P,Foufelle F

更新日期：2011-01-05 00:00:00

abstract：:AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sites including the 14-3-3 binding phospho-Thr649 (equivalent to Thr642 in human AS160). To define physiological roles of AS160-Thr649...

journal_title：Cell metabolism

authors： Chen S,Wasserman DH,MacKintosh C,Sakamoto K

更新日期：2011-01-05 00:00:00

abstract：:The brain is the most cholesterol-rich organ in the body, most of which comes from in situ synthesis. Here we demonstrate that in insulin-deficient diabetic mice, there is a reduction in expression of the major transcriptional regulator of cholesterol metabolism, SREBP-2, and its downstream genes in the hypothalamus a...

journal_title：Cell metabolism

authors： Suzuki R,Lee K,Jing E,Biddinger SB,McDonald JG,Montine TJ,Craft S,Kahn CR

更新日期：2010-12-01 00:00:00

abstract：:Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To investigate the latter, w...

journal_title：Cell metabolism

authors： Williams SL,Huang J,Edwards YJ,Ulloa RH,Dillon LM,Prolla TA,Vance JM,Moraes CT,Züchner S

更新日期：2010-12-01 00:00:00

abstract：:The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm)⁻(/)⁻ mice in which TIF2 was selectively ablated in skeletal musc...

journal_title：Cell metabolism

authors： Duteil D,Chambon C,Ali F,Malivindi R,Zoll J,Kato S,Geny B,Chambon P,Metzger D

更新日期：2010-11-03 00:00:00

abstract：:TRPM channels have emerged as key mediators of diverse physiological functions. However, the ionic permeability relevant to physiological function in vivo remains unclear for most members. We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) an...

journal_title：Cell metabolism

authors： Georgiev P,Okkenhaug H,Drews A,Wright D,Lambert S,Flick M,Carta V,Martel C,Oberwinkler J,Raghu P

更新日期：2010-10-06 00:00:00

abstract：:The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...

journal_title：Cell metabolism

authors： Wunderlich FT,Ströhle P,Könner AC,Gruber S,Tovar S,Brönneke HS,Juntti-Berggren L,Li LS,van Rooijen N,Libert C,Berggren PO,Brüning JC

更新日期：2010-09-08 00:00:00

abstract：:Oxidative stress causes mitochondrial dysfunction and metabolic complications through unknown mechanisms. Cardiolipin (CL) is a key mitochondrial phospholipid required for oxidative phosphorylation. Oxidative damage to CL from pathological remodeling is implicated in the etiology of mitochondrial dysfunction commonly ...

journal_title：Cell metabolism

authors： Li J,Romestaing C,Han X,Li Y,Hao X,Wu Y,Sun C,Liu X,Jefferson LS,Xiong J,Lanoue KF,Chang Z,Lynch CJ,Wang H,Shi Y

更新日期：2010-08-04 00:00:00

abstract：:In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a...

journal_title：Cell metabolism

authors： Rajan A,Perrimon N

更新日期：2010-07-07 00:00:00

abstract：:Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the development of obesity-associated metabolic disorders. Here, we show that the macrophage-derived soluble protein AIM is endocytosed into adipocytes via CD36. Within adipocytes, AIM associates...

journal_title：Cell metabolism

authors： Kurokawa J,Arai S,Nakashima K,Nagano H,Nishijima A,Miyata K,Ose R,Mori M,Kubota N,Kadowaki T,Oike Y,Koga H,Febbraio M,Iwanaga T,Miyazaki T

更新日期：2010-06-09 00:00:00

abstract：:Factor inhibiting HIF-1alpha (FIH) is an asparaginyl hydroxylase. Hydroxylation of HIF-alpha proteins by FIH blocks association of HIFs with the transcriptional coactivators CBP/p300, thus inhibiting transcriptional activation. We have created mice with a null mutation in the FIH gene and found that it has little or n...

journal_title：Cell metabolism

authors： Zhang N,Fu Z,Linke S,Chicher J,Gorman JJ,Visk D,Haddad GG,Poellinger L,Peet DJ,Powell F,Johnson RS

更新日期：2010-05-05 00:00:00

abstract：:Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain...

journal_title：Cell metabolism

authors： Zhang D,Christianson J,Liu ZX,Tian L,Choi CS,Neschen S,Dong J,Wood PA,Shulman GI

更新日期：2010-05-05 00:00:00

abstract：:The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance ...

journal_title：Cell metabolism

authors： Quarta C,Bellocchio L,Mancini G,Mazza R,Cervino C,Braulke LJ,Fekete C,Latorre R,Nanni C,Bucci M,Clemens LE,Heldmaier G,Watanabe M,Leste-Lassere T,Maitre M,Tedesco L,Fanelli F,Reuss S,Klaus S,Srivastava RK,Monory K

更新日期：2010-04-07 00:00:00

abstract：:The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. ...

journal_title：Cell metabolism

authors： Ashcroft FM

更新日期：2010-03-03 00:00:00

abstract：:Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when m...

journal_title：Cell metabolism

authors： Becker L,Gharib SA,Irwin AD,Wijsman E,Vaisar T,Oram JF,Heinecke JW

更新日期：2010-02-03 00:00:00

abstract：:The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production. ...

journal_title：Cell metabolism

authors： Cantó C,Auwerx J

更新日期：2010-01-01 00:00:00

abstract：:Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons ...

journal_title：Cell metabolism

authors： Hayes MR,Skibicka KP,Leichner TM,Guarnieri DJ,DiLeone RJ,Bence KK,Grill HJ

更新日期：2010-01-01 00:00:00

abstract：:Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR...

journal_title：Cell metabolism

authors： Kühnlein RP

更新日期：2009-12-01 00:00:00

abstract：:Genetic conservation allows ancient features of fat storage endocrine pathways to be explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to identify regulators of fat mass. When mixed with their food, E. coli bacteria, Nile red, and BODIPY-labeled fatty acids stain multiple spheri...

journal_title：Cell metabolism

authors： O'Rourke EJ,Soukas AA,Carr CE,Ruvkun G

更新日期：2009-11-01 00:00:00

abstract：:Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxi...

journal_title：Cell metabolism

authors： Chan SY,Zhang YY,Hemann C,Mahoney CE,Zweier JL,Loscalzo J

更新日期：2009-10-01 00:00:00

abstract：:Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through wh...

journal_title：Cell metabolism

authors： Ory DS

更新日期：2009-09-01 00:00:00

abstract：:Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...

journal_title：Cell metabolism

authors： Nilsson R,Schultz IJ,Pierce EL,Soltis KA,Naranuntarat A,Ward DM,Baughman JM,Paradkar PN,Kingsley PD,Culotta VC,Kaplan J,Palis J,Paw BH,Mootha VK

更新日期：2009-08-01 00:00:00

abstract：:Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2alpha). To elucidate the role of eIF2alpha phosphorylation, we engineered mice for conditional expression of homo...

journal_title：Cell metabolism

authors： Back SH,Scheuner D,Han J,Song B,Ribick M,Wang J,Gildersleeve RD,Pennathur S,Kaufman RJ

更新日期：2009-07-01 00:00:00

abstract：:Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARgamma and C/EBPalpha. Here we demonstrate that the IRE1alpha-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient mouse embryo...

journal_title：Cell metabolism

authors： Sha H,He Y,Chen H,Wang C,Zenno A,Shi H,Yang X,Zhang X,Qi L

更新日期：2009-06-01 00:00:00

abstract：:Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in g...

journal_title：Cell metabolism

authors： Roodman GD

更新日期：2009-05-01 00:00:00

abstract：:Faced with changing food availability, organisms adapt metabolism to survive. In a recent issue of Cell, Lin et al. (2009) described the acetylation of an extranuclear enzyme being regulated by acetyl-CoA. This finding connects nutrient availability, energy status, and survival. ...

journal_title：Cell metabolism

authors： de Cabo R,Navas P

更新日期：2009-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoid...

journal_title：Cell metabolism

authors： Nagai Y,Yonemitsu S,Erion DM,Iwasaki T,Stark R,Weismann D,Dong J,Zhang D,Jurczak MJ,Löffler MG,Cresswell J,Yu XX,Murray SF,Bhanot S,Monia BP,Bogan JS,Samuel V,Shulman GI

更新日期：2009-03-01 00:00:00

abstract：:Leptin signals the repletion of fat stores, acting in the CNS to permit energy utilization by a host of autonomic and neuroendocrine processes and to decrease feeding. While much recent research has focused on the leptin-regulated circuitry of the hypothalamic arcuate nucleus (ARC), the majority of brain leptin recept...

journal_title：Cell metabolism

authors： Myers MG Jr,Münzberg H,Leinninger GM,Leshan RL

更新日期：2009-02-01 00:00:00

abstract：:Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...

journal_title：Cell metabolism

authors： Moss LG,Newgard CB

更新日期：2009-01-07 00:00:00

abstract：:The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...

journal_title：Cell metabolism

authors： Xue Y,Petrovic N,Cao R,Larsson O,Lim S,Chen S,Feldmann HM,Liang Z,Zhu Z,Nedergaard J,Cannon B,Cao Y

更新日期：2009-01-07 00:00:00

abstract：:Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system w...

journal_title：Cell metabolism

authors： Hampton RY

更新日期：2008-12-01 00:00:00

abstract：:The unconventional myosin Myo1c has been implicated in insulin-regulated GLUT4 translocation to the plasma membrane in adipocytes. We show that Myo1c undergoes insulin-dependent phosphorylation at S701. Phosphorylation was accompanied by enhanced 14-3-3 binding and reduced calmodulin binding. Recombinant CaMKII phosph...

journal_title：Cell metabolism

authors： Yip MF,Ramm G,Larance M,Hoehn KL,Wagner MC,Guilhaus M,James DE

更新日期：2008-11-01 00:00:00

abstract：:Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...

journal_title：Cell metabolism

authors： Patsouris D,Li PP,Thapar D,Chapman J,Olefsky JM,Neels JG

更新日期：2008-10-01 00:00:00

abstract：:Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncov...

journal_title：Cell metabolism

authors： Doria A,Patti ME,Kahn CR

更新日期：2008-09-01 00:00:00

abstract：:Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice. ...

journal_title：Cell metabolism

authors： Richter EA,Kiens B,Wojtaszewski JF

更新日期：2008-08-01 00:00:00

abstract：:Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP...

journal_title：Cell metabolism

authors： Dyachok O,Idevall-Hagren O,Sågetorp J,Tian G,Wuttke A,Arrieumerlou C,Akusjärvi G,Gylfe E,Tengholm A

更新日期：2008-07-01 00:00:00

abstract：:The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including I...

journal_title：Cell metabolism

authors： Kang K,Reilly SM,Karabacak V,Gangl MR,Fitzgerald K,Hatano B,Lee CH

更新日期：2008-06-01 00:00:00